Tyrex and Fatex are database applications for research on endocrine and metabolic diseases. These applications are developed at 3rd Medical Department, 1st Faculty of Medicine, Charles University in Prague. Application's aim is to store detailed data of patients' examinations, sonographical examinations and treatments with thyroid gland and metabolic diseases. Purpose of the applications is to facilitate data processing for clinical research, which is very difficult, because information stored in hospital information system doesn't contain detailed records from medical examinations. Also, searching for several entries is slow. As well, application allows automated import of biochemical results from hospital information system. This function provides physicians wide range of possibilities in data processing and comparison in relation to treatments. Effective feature of this application is faster writing medical reports stored in information system because they are automatically generated from application's database.